SFB 1208 Lecture: Roland Wedlich-Söldner, University of Münster

Datum / Uhrzeit:
10.10.19   /  16:30 - 18:00

SFB 1208

Hörsaal 6E, Geb. 26.11


Roland Wedlich-Söldner, University of Münster

"Calcium-mediated actin reset (CaAR) mediates acute cell adaptation"

In my presentation I will demonstrate how mammalian cells can ensure that its diverse actin assemblies are kept in equilibrium during global reorganization in response to acute signals or stress. A rapid and transient actin reset is triggered by increased intracellular calcium levels. Within seconds of calcium influx, the formin INF2 stimulates filament polymerization at the endoplasmic reticulum (ER), while cortical actin is disassembled. The reaction is then reversed within a few minutes. This Calcium-mediated Actin Reset (CaAR, Fig. 1) occurs in a wide range of mammalian cell types and in response to many physiological cues. CaAR leads to transient immobilization of organelles, drives reorganization of actin during cell cortex repair and induces long-lasting changes in gene expression. Ongoing projects aims to dissect structural features in INF2 that mediate its versatile cellular functions, understand the role of CaAR during plasma membrane repair and elucidate the role of INF2 mutations and CaAR for the function and pathology of the kidney.

Short CV:
Roland Wedlich-Söldner studied Biology in Munich and Marburg. He did his PhD with Regine Kahmann and Gero Steinberg 
followed by a postdoc from 2002-2005 with Rong Li at Harvard Medical School in Boston. He then started his own research group at the MPI of Biochemistry in Martinsried before joining Münster University as CiM professor for Multiscale Imaging in Cell Biology and head of the Institute of Cell Dynamics and Imaging (ICDI) in 2013. Research at the ICDI employs quantitative approaches with a methodical focus on state of the art fluorescence microscopy techniques. The biological focus lies on understanding plasma membrane organization and cortical actin dynamics, in particular during acute stimulation of cells.


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