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Review on stereoselective domino Heck-Suzuki reactions published as ‘very important paper’ in Eur. J. Org. Chem.

M. Braun, Eur. J. Org. Chem. 2022, e202201282

Exocyclic tetra-substituted carbon-carbon double bonds in uniform configuration and creation of tertiary or quaternary stereogenic centers in a diastereoselective or enantioselective manner – these structural motives are accessible by a cascade consisting of a Mizoroki-Heck reaction and subsequent Suzuki-Miyaura coupling. Two carbon-carbon bonds are formed due to suitable palladium catalysts that guarantee a high degree of stereoselectivity.

In the research group of Prof. Manfred Braun, contributions to this topic had been delivered by Dr. Brigitte Bollig, born Richrath, and Dr. Raphael Opitz in their dissertations at HHU.


M. Braun, Stereoselective Domino Heck-Suzuki Reactions, Eur. J. Org. Chem. 2022, e202201282



Kategorie/n: Chemie Aktuelles, Chemie Aktuelle Publikation